Benzylidene cyclohexanone, cyclopentanone and acteone derivatives and therapeutic methods of using same are disclosed. The compounds are non-toxic and exhibit potent anti-inflammatory, antibacterial and antioxidation activity. Also, certain compounds of the invention inhibit glutathione S-transferase ("GST"), but do not irritate the gastrointestinal tract. Pharmaceutical compositions containing the compounds of the invention and pharmaceutically acceptable carriers are also disclosed.
RELATED APPLICATIONS
This application is a continuation-in-part of pending U.S. patent application Ser. No. 09/747,585, entitled, "Derivatives of Benzilidine Cyclohexanone, Benzilidine Cyclopentanone, and Benzilidine Acetone and their Synthesis," filed on Dec. 21, 2000 now abandoned, which is a continuation of allowed U.S. patent application Ser. No. 09/026,624, entitled "Derivatives of Benzilidine Cyclohexanone, Benzilidine Cyclopentanone, and Benzilidine Acetone and their Synthesis," filed on Feb. 20, 1998, which claims priority to Indonesian Patent Application Serial No. P-970482, filed on Feb. 20, 1997. The disclosures of all of the aforementioned patent applications are expressly incorporated herein by reference.
