Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.
RELATED APPLICATIONS
This application is a divisional of U.S. application Ser. No. 09/941,690, filed Aug. 30, 2001, now U.S. Pat. No. 6,482,846 which is a continuation of U.S. application Ser. No.09/518,541, filed Mar. 3, 2000, issued as U.S. Pat. No. 6,323,234, which is a continuation of U.S. application Ser. No. 08/931,564, filed Sep. 16, 1997, issued as U.S. Pat. No. 6,057,347, which is a a continuation of U.S. application Ser. No. 08/543,208, filed Oct. 13, 1995, issued as U.S. Pat. No. 5,703,073, which is a continuation in-part of U.S. application Ser. No. 08/425,090 filed Apr. 19, 1995, issued as U.S. Pat. No. 6,051,588. This application is also related to U.S. Pat. Nos. 5,703,073, 6,043,232, 6,043,233, 6,048,858, 6,051,588, 6,057,347, 6,083,515, 6,143,734 and 6,323,234.
