INTRODUCTION
This application is a continuation of PCT Application No. PCT/US00/25799 filed Sep. 20, 2000, which claims the benefit of U.S. Provisional Patent Application No. 60/155,019 filed Sep. 21, 1999.
The present invention provides novel diphenyl ethene compounds and pharmaceutically-acceptable salts thereof. Also provided are methods for making the compounds of the invention as well as methods for the use thereof in the treatment of immune, inflammatory, and auto-immune diseases.
In one aspect, the present invention provides compounds having formula I or IV as shown below: ##STR00001## as further defined herein. In additional aspects, the present invention provides compositions and kits comprising the compounds of the invention and methods for their use, for example, for the prevention or treatment of a cancer.