The noninvasive measurement system provides a technique for manipulating wave data. In particular, wave data reflected from a biological entity is received, and the reflected wave data is correlated to a substance in the biological entity. The wave data may comprise light waves, and the biological entity may comprise a human being or blood. Additionally, a substance may comprise, for example, a molecule or ionic substance. The molecule may be, for example, a glucose molecule. Furthermore, the wave data is used to form a matrix of pixels with the received wave data. The matrix of pixels may be modified by techniques of masking, stretching, or removing hot spots. Then, the pixels may be integrated to obtain an integration value that is correlated to a glucose level. The correlation process may use a lookup table, which may be calibrated to a particular biological entity. Moreover, an amplitude and phase angle may be calculated for the reflected wave data and used to identify a glucose level in the biological entity. The glucose level may be displayed on a monitor attached to the computer. The computer may be a portable, self-contained unit that comprises a data processing system and a wave reflection capture system. On the other hand, the computer may be attached to a network of other computers, wherein the reflected wave data is received by the computer and forwarded to another computer in the network for processing.
This application is a continuation and claims priority from International Application No. PCT/US99/21680, "NONINVASIVE MEASUREMENT OF BLOOD SUGAR BASED ON OPTOELECTRONIC OBSERVATIONS OF THE EYE", filed on Sep. 17, 1999, by Walter K. Proniewicz and Dale E. Winther, which is incorporated by reference herein and which claims priority to U.S. Provisional Patent Application No. 60/100,804, "BLOOD SUGAR MEASUREMENT THROUGH THE EYEBALL", filed on Sep. 18, 1998, by Walter K. Proniewicz and Dale E. Winther, which is incorporated by reference herein.
A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.
A method and system for non-invasively measuring the concentration of an optically-active substance in a subject are provided. The system includes a light source adapted to transmit light towards a subject or object having a concentration of an optically-active substance, a polarizer positioned between the light source and the subject, an image capturing device, and a processor. The image capturing device is positioned to receive light reflected from the subject and create a measured image therefrom. The measured image defines measured light intensity data. The processor is configured to calculate a concentration of the optically-active substance based on a selected portion of the measured light intensity data.
An apparatus for measuring a concentration of a substance in an eye (13) includes a measurement light source (4) producing a measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient. The apparatus further includes a reference light source (6) producing a reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. At least a portion of the measurement light beam retro-reflects from the retina (17) and at least a portion of the reference light beam retro-reflects from the retina (17). The apparatus further includes a detector (9) responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal.
