Polypeptides, in particular the polypeptide of formula I: and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.
This is a continuation of application Ser. No. 08/427,170, filed Apr. 24, 1995, now U.S. Pat. No. 6,245,739; which is a continuation of application Ser. No. 07/926,371, filed Aug. 10, 1992, now U.S. Pat. No. 5,464,822; which is a continuation of application Ser. No. 07/536,096, filed Jun. 8, 1990, now abandoned, the entire content of which is hereby incorporated by reference in this application.
