The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
RELATED APPLICATIONS
This application is a division of application Ser. No. 09/748,599, filed Dec. 26, 2000, now U.S. Pat. No. 6,462,075 which claims priority from provisional application Ser. No. 60/171,883 filed Dec. 23, 1999.
Compositions of matter and methods wherein chalcone and flavone derivatives are administered to human or veterinary patients for the treatment of bladder or urinary tract cancer. Compounds of the invention include 2'-hydroxy-4,4',6'-trimethoxychalcone (Flavokawain A).
