Pharmaceutical compositions of modafinil compounds, including pharmaceutical, non-aqueous compositions of modafinil compounds in organic solvents and pharmaceutical compositions of a modafinil compound in solid dispersions, are disclosed, along with their use in the treatment of diseases.
This Application is a continuation-in-part of U.S. application Ser. No. 09/974,473 filed Oct. 10, 2001, now U.S. Pat. No. 6,484,363 which claims benefit of U.S. Provisional Application Ser. No. 60/239,488 filed Oct. 11, 2000.
The invention relates to a process for the preparation of crystalline forms of the optical enantiomers of modafinil, comprising stages comprising: i) dissolving one of the optical enantiomers of modafinil in a solvent other than ethanol, ii) crystallising the modafinil enantiomer, iii) recovering the crystalline form of the modafinil enantiomer so obtained. The invention also relates to a process for the preparation of the optical enantiomers of modafinil.
