The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme ##STR1##
This application is a 371 application of PCT/US01/12490 filed Apr. 16, 2001, which claims the benefit of priority to U.S. provisional application Ser. No. 60/197,485 filed Apr. 17, 2000.
