The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of the formula (1): ##STR1## in which Z.sup.1 and Z.sup.2 are moieties derived from sugar. The invention also provides methods for preparing such compounds. Lyophilizing a mixture comprising a boronic acid compound and a moiety derived from sugar produces a stable composition that readily releases the boronic acid compound upon reconstitution in aqueous media.
CROSS-REFERENCE TO RELATED APPLICATIONS
This patent application is a continuation of U.S. patent application Ser. No. 10/056,567, filed Jan. 25, 2002, now U.S. Pat. No. 6,713,446, and a continuation of U.S. patent application Ser. No. 10/056,563, filed Jan. 25, 2002, now U.S. Pat. No. 6,699,835, both of which claim the benefit of U.S. Provisional Patent Application No. 60/264,160, filed Jan. 25, 2001.
Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
