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Indolyl and dihydroindolyl derivatives, their manufacture and use as pharmaceutical agents
   
Document Number
US Patent 6995263
Issued Date
February 7, 2006
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Abstract
This invention relates to compounds of the formula ##STR00001## wherein one of R.sup.6, R.sup.7 and R.sup.8 is ##STR00002## and X, Y.sup.1 to Y.sup.4, R.sup.1 to R.sup.14 and n are as defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR.delta. and/or PPAR.alpha. agonists.
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Number of Claims:
25
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Owner
Published
February 7, 2006
Application Number
10/978,144
Filed
October 29, 2004
US Classification
544/333   546/277.4
Int'l Classification
C07D   401/04   (20060101)   C07D   401/14   (20060101)   C07D   403/02   (20060101)  
Assistant Examiner
Priority Data
Nov 05, 2003 [EP] 03104083
USPTO Field of Search
546/277.4   544/333  
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This invention relates to compounds of the formula ##STR00001## wherein one of R.sup.6, R.sup.7 or R.sup.8 is ##STR00002## and all enantiomers and pharmaceutically acceptable salts and/or esters thereof as well as pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR.delta. and/or PPAR.alpha. agonists.

7405236 - Indole derivatives comprising an acetylene group - Owned by Hoffman-La Roche Inc. (Nutley, NJ)

This invention is directed to compounds of the formula (I): ##STR00001## wherein one of R.sup.6, R.sup.7, R.sup.8 and R.sup.9 is ##STR00002## and X, R.sup.1 to R.sup.12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention is also directed to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR.delta. and/or PPAR.alpha. agonists.

Claims
Description
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