A medical fluid suctioning device for selectively applying varied levels of suction pressure at a device-tissue interface includes a direct "trumpet"-type control mechanism in conjunction with a "venturi"-type control. A valve manifold is adapted to couple a vent pathway and a suction pathway simultaneously to the vacuum conduit adapted for connection to a vacuum source. The amount of resistance to flow due to vacuum pressure is adjusted simultaneously in both the vent pathway and the suction pathway in order to achieve controlled, selected levels of suction. Similarly shaped valve apertures are provided in inverse and reciprocal orientation along an axis of motion of a valve manifold. The apertures translate across ports to the suction and venting pathways simultaneously to vary applied suction to those pathways inversely. The shaped valve apertures preferably have diminished elliptical shapes having an elongate axis with an increasing cross-sectional area going from a transverse short axis to a transverse wide axis along the axis of motion of the valve manifold. The diminished elliptical shapes are inversely oriented relative to each other as regards the positioning of their wide and short transverse axis along the axis of motion.
CROSS REFERENCE TO A RELATED APPLICATION
This application is a continuation of patent application Ser. No. 09/421,353 filed Oct. 25, 1999 now U.S. Pat. No. 6,471,667 which is a continuation of patent application Ser. No. 08/839,614, filed Apr. 14, 1997 and entitled "MEDICAL SUCTIONING APPARATUS AND METHODS OF USE," now U.S. Pat. No. 5,971,956, and a division of patent application Ser. No. 08/838,078 filed Apr. 14, 1997 now U.S. Pat. No. 6,331,172 and entitled "APPLICATOR FOR DISPENSING MEASURED QUANTITIES WITH USE OF CONTROLLED SUCTION" the disclosures of which applications are hereby incorporated herein by reference thereto.
A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.
