The present invention provides O.sup.2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates) of the formula ##STR00001## in which R and R.sup.22are as described herein. Also provided is a composition comprising such a compound and a carrier. The 1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates compounds release nitric oxide under physiological conditions and are useful for treating biological disorders.
CROSS-REFERENCE TO RELATED PATENT APPLICATIONS
This application is a divisional of U.S. patent application Ser. No. 10/337,495, filed Jan. 7, 2003, now U.S. Pat. No. 6,911,433. which is a divisional of U.S. patent application Ser. No. 09/254,301, filed May 3, 1999, now U.S. Pat. No. 6,610,660, which is a U.S. national phase of International Patent Application No. PCT/US97/17267, filed Sep. 26, 1997, which claims the benefit of U.S. Provisional Patent Application No. 60/051,696, filed Jul. 3, 1997, U.S. Provisional Patent Application No. 60/045,917, filed May 7, 1997, and U.S. Provisional Patent Application No. 60/026,816, filed Sep. 27, 1996.
![O.sup.2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates - US Patent 7081524 - Page 1](http://www.wikipatents.com/osup2-substituted-1-2-carboxylatopyrrolidin-1-yldiazen-1-ium-12-diolates/T/US7081524-1.jpg "O.sup.2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates - US Patent 7081524 - Page 1")
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![O.sup.2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates - US Patent 7081524 - Page 3](http://www.wikipatents.com/osup2-substituted-1-2-carboxylatopyrrolidin-1-yldiazen-1-ium-12-diolates/T/US7081524-3.jpg "O.sup.2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates - US Patent 7081524 - Page 3")
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![O.sup.2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates - US Patent 7081524 - Page 5](http://www.wikipatents.com/osup2-substituted-1-2-carboxylatopyrrolidin-1-yldiazen-1-ium-12-diolates/T/US7081524-5.jpg "O.sup.2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates - US Patent 7081524 - Page 5")
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