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Method and apparatus for separation of particles in a microfluidic device
   
Document Number
US Patent 7094354
Issued Date
August 22, 2006
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Abstract
A microfluidic device provides separation of particles in a liquid sample, particularly, separation of a sample of whole blood into its components for further analysis. Separation into red blood cells and plasma occurs within a few seconds after the blood sample has been transferred into a separation chamber with the application of centrifugal force of less than about five times gravity. With the application of greater force measurement of hematocrit is possible.
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Number of Claims:
29
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Owner
Bayer Healthcare LLC (Tarrytown, NY)
Published
August 22, 2006
Application Number
10/326,156
Filed
December 19, 2002
US Classification
210/787   210/198.1 422/103 422/72 436/45
Int'l Classification
G01N   9/30   (20060101)  
USPTO Field of Search
210/787   210/198.1   422/64   422/67   422/72   422/103   435/2   435/287.1   436/45  
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The comprises at least one sample receiving chamber for a sample liquid, and a distributor channel for sample liquid connected to said at least one sample receiving chamber, with at least one such distributor channel extending from each sample receiving chamber. The sample support further comprises at least one reaction chamber entered by an inflow channel branched off said at least one distributor channel, and a venting opening for each reaction chamber. Each distributor channel and each inflow channel are dimensioned to have the liquid transport through the distributor and inflow channels effected by capillary forces. In each reaction chamber, the entrance region of the inflow channel is provided with a means for generating a capillary force causing the sample liquid to flow from the inflow channel into the reaction chamber.

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