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Total synthesis of daurichromenic acid
   
Document Number
US Patent 7102020
Issued Date
September 5, 2006
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Inventors
Jin; Zhendong (Coralville, IA)
Kang; Ying (Iowa City, IA)
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Abstract
The present invention provides a method to prepare 2H-benzo[6]pyrans, such as the anti-HIV natural product daurichromenic acid (1a), by microwave-assisted tandem aldol reaction of a phenolic enolate followed by intramolecular SN2' type cyclization to form the 2H-benzo[6]pyran core structure.
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Number of Claims:
13
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Published
September 5, 2006
Application Number
10/739,882
Filed
December 18, 2003
US Classification
549/399   549/406
Int'l Classification
C07D   311/74   (20060101)   C07D   311/76   (20060101)  
Assistant Examiner
Parent Case
CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S. provisional application Ser. No. 60/435,417, filed Dec. 20, 2002.
USPTO Field of Search
549/399   549/400   514/454   514/456   8/579   504/292   204/157   204/69  
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