Method and apparatus, including computer program products, implement techniques for operating a mass spectrometer that includes a source of ions, a mass analyzer, and a detector, in which a gain of the detector or the number of ions detected by the detector is calculated based on intensity measurements for ions having a plurality of different m/z values. In particular implementations, the detector gain or the number of ions detected by the detector can be calculated based on a ratio of or difference between intensity values for at least two of the ions having different m/z values.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims the benefit of U.S. Provisional Application No. 60/476,842, filed on Jun. 5, 2003, which is incorporated by reference herein.