October 17, 2006

The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.

61

October 17, 2006

09/850,858

May 8, 2001

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C07D   209/56   (20060101)   A61K   31/46   (20060101)  

CROSS-REFERENCE TO RELATED APPLICATIONS This application claims benefit of U.S. provisional Application Ser. No. 60/202,947 filed May 9, 2000.

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