With an object of providing an agent for treating hepatic disease by inhibiting occurrence of hepatic disease, in particular portal venous invasion, there is disclosed an agent for treating or preventing hepatic disease containing menatetrenone as an active ingredient thereof. This agent for treating or preventing hepatic disease is effective against hepatic cancer, in particular DCP (des-.gamma.-carboxy prothrombin) positive hepatic cancer. Moreover, the agent for treating or preventing hepatic disease containing menatetrenone as an active ingredient thereof according to the present invention exhibits remarkable effects in improving the prognosis after hepatic cancer treatment, and exhibits excellent effects as an agent for inhibiting the recurrence of hepatic cancer.
