The present invention provides a compound of formula (I): ##STR00001## wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.
It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an organ-independent elimination mechanism and thereby providing a more predictable and reproducible pharmacodynamic profile. The compounds of the present invention are suitable for therapeutic purposes, including sedative-hypnotic, anxiolytic, muscle relaxant and anticonvulsant purposes and are useful to be administered intravenously in the following clinical settings: preoperative sedation, anxiolysis, and amnestic use for perioperative events; conscious sedation during short diagnostic, operative or endoscopic procedures; as a component for the induction and maintenance of general anesthesia, prior and/or concomitant to the administration of other anesthetic agents; ICU sedation.
The present invention provides a compound of formula (I): ##STR00001## wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.
The present invention provides a compound of formula (I): ##STR00001## wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.
The present invention provides a compound of formula (I): ##STR00001## wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.
