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Dendritic chemiluminescent substrates
 
   
Document Number
US Patent 7214546
Issued Date
May 8, 2007
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Inventors
Sparks; Alison L. (North Andover, MA)
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Abstract
Chemiluminescent substrate delivery systems comprising a conjugate of a dendrimer and at least one chemiluminescent substrate are provided. The substrate delivery systems can also include a chemiluminescence enhancer. The dendrimer/chemiluminescent substrate conjugates can be used in kits including an enzyme capable of activating the chemiluminescent substrate to produce a peroxygenated intermediate that decomposes to produce light. The dendrimer/chemiluminescent substrate conjugates can be used in assays to detect the presence of an analyte (e.g., an enzyme, an antibody, an antigen or a nucleic acid) in a sample.
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Number of Claims:
20
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Owner
Applera Corporation (Bedford, MA)
Published
May 8, 2007
Application Number
10/038,626
Filed
January 8, 2002
US Classification
436/546   436/172 436/528 436/531 436/805
Int'l Classification
G01N   33/533   (20060101)   G01N   21/76   (20060101)   G01N   33/544   (20060101)   G01N   33/545   (20060101)  
Parent Case
CROSS-REFERENCES TO RELATED APPLICATIONS This application is based on U.S. Provisional Application No. 60/259,870, filed Jan. 8, 2001, and U.S. Provisional Application No. 60/286,383, filed Apr. 26, 2001.
USPTO Field of Search
436/546   436/528   436/531   436/172   436/805  
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