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Anthranilamides and methods of their use
 
   
Document Number
US Patent 7235690
Issued Date
June 26, 2007
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Abstract
The present invention is related to anthranilamides of formula I, ##STR00001## in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations containing them. The compounds act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. The compounds are therefore suitable for use as novel antiarrhythmic agents for the treatment and prophylaxis of atrial arrhythmias (e.g., atrial fibrillation (AF) or atrial flutter).
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Number of Claims:
24
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Owner
Sanofi-Aventis Deutschland GmbH (Frankfurt am Main,DE)
Published
June 26, 2007
Application Number
10/132,163
Filed
April 26, 2002
US Classification
564/91   546/172 546/265 546/283.4 546/333 546/334 548/204 548/309.7 548/336.1 548/375.1 549/493 564/92
Int'l Classification
C07C   311/00   (20060101)  
Attorney/Law Firm
Priority Data
Apr 28, 2001 [DE] 101 21 003
USPTO Field of Search
564/91   564/92   546/172   546/265   546/283.4   546/333   546/334   548/204   548/309.7   548/336.1   548/375.1   549/493   514/604   514/461   514/427   514/406   514/399   514/394   514/365   514/336   514/332   514/311   514/307   514/357  
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