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Document Number
US Patent 7244600
Issued Date
July 17, 2007
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Abstract
Disclosed is a water-soluble PQQGDH wherein two subunits are linked together via a disulfide bond. The water-soluble PQQGDH of the invention exhibits improved thermal stability.
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Number of Claims:
8
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Published
July 17, 2007
Application Number
10/471,552
Filed
March 7, 2002
US Classification
435/190   204/403.04 204/403.11 435/252.3 435/320.1 435/4 435/440 435/6 435/69.1 435/71.1 536/23.2 536/23.7
Int'l Classification
C12N   9/04   (20060101)   C07H   21/04   (20060101)   C12M   1/00   (20060101)   C12N   1/20   (20060101)   C12N   15/00   (20060101)   C12Q   1/00   (20060101)   C12P   21/04   (20060101)   C12Q   1/68   (20060101)  
Examiner
Assistant Examiner
Priority Data
Mar 13, 2001 [JP] 2001-070413
USPTO Field of Search
435/190   435/440   435/252.3   435/320.1   435/4   435/6   435/18   435/25   435/69.1   435/71.1   536/23.2   536/23.7  
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The present invention relates to a glucose sensor (2) including an electrode (32) which includes a conductive component and glucose dehydrogenase immobilized to the conductive component. As the glucose dehydrogenase, use is made of a protein complex including a catalytic activity subunit which has glucose dehydrogenase activity, and an electron mediator subunit for supplying an electron donated from the catalytic activity subunit to the conductive component. Preferably, the glucose sensor (2) is designed to continuously measure the glucose level or successively measure the glucose level a plurality of times.

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Description
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