Nonmetallic, chiral organic catalysts are used to catalyze enantioselective fluorination of enolizable aldehydes. Reaction systems composed of an enolizable aldehyde, an electrophilic fluorination reagent, and a nonmetallic chiral catalyst in the form of an imidazolidinone salt are also provided.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims priority under 35 U.S.C. .sctn.119(e)(1) to provisional U.S. Patent Application Ser. Nos. 60/644,549, filed Jan. 18, 2005, and 60/668,533, filed Apr. 5, 2005. The disclosures of the aforementioned applications are incorporated by reference in their entireties.
