A technique for performing signal integrity analysis of a system includes providing a stimulus pattern and a model of the system and performing analog simulation of the model utilizing the stimulus pattern. The stimulus pattern includes sequences of signal transitions with associated transition times and the sequences of signal transitions conform to a bus protocol and the associated transition times are according to characteristics of the system. The stimulus pattern is generated by initializing each of the sequences of signal transitions to an initial signal value and the associated transition times to an initial time, generating subsequent signal values and subsequent transition times by applying protocol rules and calculating timing adjustments for each of a list of transactions; the subsequent signal values and subsequent transition times to be added to the sequences of signal transitions.