Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
This application is a continuation of U.S. Ser. No. 08/925,779, filed Sep. 9, 1997 (U.S. Pat. No. 6,245,889); which is a continuation of U.S. Ser. No. 07/721,847, filed Jun. 14, 1991 (U.S. Pat. No. 6,150,328). U.S. Ser. No. 07/721,847 is a continuation-in-part of two applications (U.S. Ser. Nos. 07/493,272, filed Mar. 14, 1990 (abandoned) and 07/655,579 filed Mar. 18, 1991 (U.S. Pat. No. 5,618,924)). U.S. Ser. No. 07/493,272 is a continuation in part of two applications (U.S. Ser. Nos. 07/406,217, filed Sep. 12, 1989 (abandoned) and 07/378,537 filed Jul. 11, 1989 (U.S. Pat. No. 5,166,058)). U.S. Ser. No. 07/655,579 is a divisional of U.S. Ser. No. 07/179,100, filed Apr. 8, 1988 (U.S. Pat. No. 5,013,649), while U.S. Ser. No. 07/378,537 is a continuation in part of U.S. Ser. No. 07/179,100. Applicants claim priority to all of these applications.
This application is a continuation-in-part of U.S. Nos. 493,272 filed Mar. 14, 1990 (which is a CIP of 406,217 filed Sep. 12, 1989); 378,537 filed Jul. 11, 1989; and 655,579 filed Feb. 14, 1991 which is a divisional of U.S. Ser. No. 179,100 filed Apr. 8, 1988 (now U.S. Pat. No. 5,013,649) which is a continuation-in-part of U.S. Ser. Nos. 028,285 filed Mar. 20, 1987 now abandoned; 943,332 filed Dec. 17, 1986 now abandoned; and 880,776 filed Jul. 1, 1986 now abandoned.
