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Mandelates salts of substituted tetracyclic tetrahydrofuran derivatives
   
Document Number
US Patent 7317115
Issued Date
January 8, 2008
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Abstract
The object of the present invention is a novel mandelate salt of a substituted tetracyclic tetrahydrofuran derivative according to Formula (I) ##STR00001## the N-oxide forms and the stereochemically isomeric forms thereof, wherein R.sup.1 and R.sup.2 each independently are hydrogen or C.sub.1-6alkyl and R.sup.3 and R.sup.4 each independently are hydrogen or halogen. In the foregoing definitions C.sub.1-6alkyl defines straight and branched saturated hydrocarbon radicals having from 1 to 6 carbon atoms such as, for example, methyl, ethyl, propyl, butyl, 1-methylpropyl, 1,1-dimethylethyl, pentyl or hexyl. The novel mandelate salt is not light-sensitive and is far more stable than the prior art salts at room temperature, enhanced temperature and at relative high humidities and in aqueous media. Also disclosed are pharmaceutical compositions comprising mandelate salts according to the invention, mandelate salts according to the invention for use as a medicine, a process for preparing the mandelate salts according to the invention and the use of the mandelate salts and pharmaceutical compositions comprising mandelate salts according to the invention for the treatment or the prevention of CNS disorders, cardiovascular disorders and gastrointestinal disorders.
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Number of Claims:
9
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Published
January 8, 2008
Application Number
10/491,799
Filed
November 8, 2002
US Classification
549/457  
Int'l Classification
C07D   307/77   (20060101)  
Examiner
Attorney/Law Firm
Priority Data
Nov 09, 2001 [EP] 01204465
USPTO Field of Search
549/457   514/468  
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