There is provided a pharmaceutical composition comprising (i) a compound of the formula ##STR00001## wherein: X is a hydrocarbyl ring having at least 4 atoms in the ring; K is a hydrocarbyl group; Rs is a sulphamate group; (ii) optionally admixed with a pharmaceutically acceptable carrier, diluent, excipient or adjuvant, wherein the compound is present in an amount to provide a dosage of no greater than 200 .mu.g/day.
This application is a continuation-in-part of U.S. application Ser. No. 09/755,429, filed Jan. 5, 2001, now U.S. Pat. No. 6,653,298 now allowed, which claims priority from U.K. applications 0000792.2 and 0002115.4, filed Jan. 14 and 28, 2000 and U.S. application Ser. No. 60/218,730, filed Jul. 17, 2000. Each of these applications, and each document cited in each of these applications ("application cited documents"), and each document cited or referenced in each of the application cited documents, and each document cited herein ("herein cited documents") and each document referenced or cited in each of the herein cited documents, including any specifications, instructions or product data sheets for any commercially available products mentioned herein, in any of the foregoing applications, in any of the application cited documents, in any of the herein cited documents, and in any documents incorporated into this specification, are hereby incorporated herein by reference; and, reference is explicitly made to U.S. Pat. Nos. 6,159,960, 6,083,978, 6,017,904, 6,011,024, 5,861,390, 5,830,886, 5,616,574, and 5,604,215.
Priority Data
Jan 14, 2000 [GB] 0000792.2 Jan 28, 2000 [GB] 0002115.4
