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Carnitine conjugates as dual prodrugs and uses thereof
   
Document Number
US Patent 7345190
Issued Date
March 18, 2008
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Inventors
Goel; Om P. (Ann Arbor, MI)
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Abstract
The present invention discloses novel dual prodrug compositions of Formula 1, ##STR00001## wherein A is a single bond, --O--, or --CH.sub.2--; m and n vary from 0 to 15; p and q vary from 0 to 4; B is a single bond or --CR.sup.3R.sup.4; D is selected from the group consisting --CO.sub.2R.sup.5, --OR.sup.6, --OCOR.sup.7, --SO.sub.3R.sup.8, --SO.sub.2NH.sub.2, --OPO(OR.sup.9)(OR.sup.10), --OPO(OR.sup.9)(NH.sub.2), --OPO(OR.sup.9)--O--PO(OR.sup.10)(OR.sup.11), ##STR00002## R.sup.1 to R.sup.11 are various substituents selected to optimize the physicochemical and biological properties such as, lipophilicity, toxicity, bioavailability, and pharmacokinetics of compounds of Formula 1. These compounds are useful for the treatment of various cardiovascular and neurological disorders.
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Number of Claims:
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Owner
SSV Therapeutics, Inc. (Ann Arbor, MI)
Published
March 18, 2008
Application Number
10/987,839
Filed
November 12, 2004
US Classification
560/129   560/147 560/155 560/179
Int'l Classification
C07C   69/00   (20060101)  
Examiner
Parent Case
This application claims benefit of priority of Provisional Application No. 60/518935, filed on Nov. 12, 2003.
USPTO Field of Search
560/129   560/179   560/147   560/155  
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