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Method of encapsulating metal complex within liposomes
   
Document Number
US Patent 7354567
Issued Date
April 8, 2008
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Abstract
An object of the present invention is to provide a method of producing liposome wherein a complex of a short half-life metallic radioactive nuclide such as .sup.99mTc and CD is encapsulated, with radiochemical yield and purity enabling practical application. The present invention provides a method of producing a liposome wherein a complex of a short half-life metallic radioactive nuclide and ethylenedicysteine (CD) is encapsulated, which comprises mixing a complex of a short half-life metallic radioactive nuclide and N-[2-(1H-pyrrolylmethyl)]-N'-(4-penten-3-on-2)-ethane-1,2-diamine with an ethylenedicysteine (CD)-encapsulated liposome, and incubating the mixture.
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Number of Claims:
4
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Owner
Published
April 8, 2008
Application Number
10/503,139
Filed
February 25, 2003
US Classification
424/1.21   424/1.11 424/1.53
Int'l Classification
A61K   51/00   (20060101)   A61M   36/14   (20060101)  
Assistant Examiner
Attorney/Law Firm
Priority Data
Feb 26, 2002 [JP] 2002-049037
USPTO Field of Search
424/1.11   424/1.21  
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