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| United States Patent | 7365858 |
| Link to this page | http://www.wikipatents.com/7365858.html |
| Inventor(s) | Fang-Yen; Christopher M. (Somerville, MA), Popescu; Gabriel (Brighton, MA), Yang; Changhuei (Pasadena, CA), Wax; Adam (Chapel Hill, NC), Dasari; Ramachandra R. (Lexington, MA), Feld; Michael S. (Newton, MA) |
| Abstract | Preferred embodiments of the present invention are directed to systems for
phase measurement which address the problem of phase noise using
combinations of a number of strategies including, but not limited to,
common-path interferometry, phase referencing, active stabilization and
differential measurement. Embodiment are directed to optical devices for
imaging small biological objects with light. These embodiments can be
applied to the fields of, for example, cellular physiology and
neuroscience. These preferred embodiments are based on principles of
phase measurements and imaging technologies. The scientific motivation
for using phase measurements and imaging technologies is derived from,
for example, cellular biology at the sub-micron level which can include,
without limitation, imaging origins of dysplasia, cellular communication,
neuronal transmission and implementation of the genetic code. The
structure and dynamics of sub-cellular constituents cannot be currently
studied in their native state using the existing methods and technologies
including, for example, x-ray and neutron scattering. In contrast, light
based techniques with nanometer resolution enable the cellular machinery
to be studied in its native state. Thus, preferred embodiments of the
present invention include systems based on principles of interferometry
and/or phase measurements and are used to study cellular physiology.
These systems include principles of low coherence interferometry (LCI)
using optical interferometers to measure phase, or light scattering
spectroscopy (LSS) wherein interference within the cellular components
themselves is used, or in the alternative the principles of LCI and LSS
can be combined to result in systems of the present invention. |
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Title Information  |
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| Inventor |
Fang-Yen; Christopher M. (Somerville, MA) , Popescu; Gabriel (Brighton, MA) , Yang; Changhuei (Pasadena, CA) , Wax; Adam (Chapel Hill, NC) , Dasari; Ramachandra R. (Lexington, MA) , Feld; Michael S. (Newton, MA) |
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| Publication Date |
April 29, 2008 |
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| Filing Date |
April 13, 2004 |
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| Parent Case |
CROSS REFERENCES TO RELATED APPLICATIONS
The present application is a continuation-in-part of U.S. patent
application Ser. No. 10/024,455, filed Dec. 18, 2001 now U.S. Pat. No.
6,934,035, and claims the benefit of U.S. Provisional Application No.
60/479,732, filed Jun. 19, 2003. The entire contents of the above
applications are incorporated herein by reference in their entirety. |
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Title Information |
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