Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
CROSS REFERENCE TO OTHER APPLICATIONS
This application is a continuation of U.S. application Ser. No. 09/752,867, filed Dec. 30, 2000 now U.S. Pat. No. 7,186,397, which is a divisional of U.S. application Ser. No. 09/477,072, filed Jan. 3, 2000, now U.S. Pat. No. 6,221,334, which is a divisional of U.S. application Ser. No. 09/080,157, filed May 16, 1998, now U.S. Pat. No. 6,093,382, the contents of all of which are hereby incorporated by reference in their entirety.
