The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, optionally with a carrier. Also provided by the present invention are vaccines comprising the adjuvants of the present invention and an antigen. Further provided are methods of manufacture of the adjuvants and vaccines of the present invention and their use as medicaments. Methods of treating an individual susceptible to or suffering from a disease by the administration of the vaccines of the present invention are also provided.
This is a divisional of application Ser. No. 09/690,921 filed Oct. 18, 2000 now U.S. Pat. No. 6,544,518; which is a Continuation-in-part of Application Nos. PCT/EP00/02920 filed Apr. 4, 2000 and Ser. No. 09/301,829 filed Apr. 29, 1999 now U.S. Pat. No. 6,558,670; which claims priority of Great Britain Application No. GB 9908885.8 filed Apr. 19, 1999.
