P38 MAPK pathway predicts endocrine-resistant growth of human breast cancer and provides a novel diagnostic and treatment target

Create Free Account | License or Sell Your Patent | WikiPatents Marketplace | WikiPatents Blog

Custom CD of patents similar to US7402402 : P38 MAPK pathway predicts endocrine-resistant growth of human breast cancer and provides a novel diagnostic and treatment target - $19.95

United States Patent

7402402

Link to this page

http://www.wikipatents.com/7402402.html

Inventor(s)

Osborne; C. Kent (Houston, TX), Schiff; Rachel (Bellaire, TX), Shou; Jiang (Houston, TX)

Abstract

Acquired and de novo endocrine resistance are major clinical problems in the management of breast cancer patients. Though the antiestrogen tamoxifen prolongs disease-free and overall survival in the adjuvant setting, and induces remissions in over half of the patients with estrogen receptor positive metastatic disease, all patients eventually acquire tamoxifen resistance. Furthermore, many of the resistant tumors actually appear to be stimulated by tamoxifen just as they are by estrogens. The present invention provides methods of predicting endocrine resistance comprising detecting the biological activity and/or expression of p38 MAPK and/or AIB1. The invention further provides methods of reducing, reversing, or preventing endocrine resistance comprising contacting a breast or prostate tumor with a p38 MAPK pathway inhibitor.

References Submit all comments and votes

*references marked with an asterisk below are user-added references

U.S. References

Add a new US reference:
[Vote on relevancy & make comments] [Display results only]
Reference	Relevancy	Comments	Reference	Relevancy	Comments
2003/0027756 Hitoshi et al. Feb,2003	Your vote accepted [0 after 0 votes]		November 1998 Feb,2003	Your vote accepted [0 after 0 votes]
[Vote on relevancy & make comments] [Display results only]

Foreign References

Other References

Add a new Other reference:
Post related web sites and other references in this section
[Vote on relevancy & make comments] [Display results only]
Reference	Relevancy	Comments
NCBF Accesion No. AY865620; Jan. 19, 2005; Homo sapiens signal transducer and activator of Transcription 1, 91kDa (STAT1) gene, complete cds; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 32. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Dumas J, et al., 2002, "Synthesis and Pharmacological Characterization of a Potent, Orally Active p. 38 Kinase Inhibitor" Bioorg Med Chem Letters 12:1559-1562. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Massarweh S et al., 2002, "Inhibition of epidermal growth factor/HER2 receptor signaling using ZD1839 (`Iressa`) restores tamoxifen sensitivity and delays resistance to estrogen deprivation in HER2-overexperession breast tumors" Proceedings of ASCO 21:33a (Abstract 130). cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Osborne CK et al., 2002, "The estrogen receptor coactivator ALB1 (SRC3) in combination with HER-2 is a prognostic and predictive marker in patients with breast cancer" Proceedings of ASCO 21:33a (Abstract 129). cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Shou J et al., 2002, "The selective epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (`Iressa`) blocks estrogen receptor/growth factor cross-talk implicated in tamoxifen resistance in breast cancer" American Association for Cancer Research, 93rd Annual Meeting, Apr. 6-10, 2002, San Francisco CA (Abstract 4964). cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Barone et al., 2001, "Inhibition of p38 Mitogen-Activated Protein Kinase Provides Neuroprotection in Cerebral Focal Ischemia" Med Res Rev. 21(2):129-145. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Driggers PH et al., 2001, "The Proto-oncoprotein Brx Activates Estrogen Receptor .beta. by a p38 Mitogen-activated Prot Kinase Pathway" J. Biol. Chem. 276(50):46792-46797. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Jacobs A et al., 2001, "Quantitative Kinetics of [.sup.124]FIAU in Cat and Man" J Nucl Med 42(3):467-475. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Legos et al., 2001, "SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia" Brain Res. 892:70-77. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
McLay LM et al., 2001, "The Discovery of RPR 200765A, a p38 MAP Kinase Inhibitor Displaying a Good Oral Anti-Arthritic Efficacy" Bioorg Med Chem. 9:537-554. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Shou J et al., 2001, "Onset of endocrine resistance in breast cancer is associated with increased active p38 MAPK" Breast Cancer Res Treat 69:254 (Abstract 272), Oct. 2001. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Katzenellenbogen BS et al., 2000, "Estrogen Receptors: Selective Ligands, Partners, and Distinctive Pharmacology" Recent Progress In Hormones Res 55:163-195. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Lee et al., 2000, "MEKK1 Activation of Human Estrogen Receptor .alpha. and Stimulation of the Agonistic Activity of 4-Hydroxytamoxifen in Endometrial and Ovarian Cancer Cells", Mol Endocrinol. 14(11):1882-1896. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Schiff R et al., 2000, Oxidative Stress and AP-1 Activity in Tamoxifen-Resistant Breast Tumors In Vivo, J Natl Cancer Inst 92(23):1926-1934. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Wunderbaldinger P et al., 2000, "New approaches for imaging in gene therapy" Eur J Radiol 34:156-165. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Thomson S et al., 1999, "MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction", Cell Dev. Biol. 10:205-214. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Lofberg M et al., 1998, "Antimyosin Scintigraphy Compared with Magnetic Resonance Imaging in Inflammatory Myopathies" Arch Neurol. 55:987-993. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Osborne CK, 1998, "Tamoxifen In The Treatment of Breast Cancer", N Engl J Med 339(22):1609-1618. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Pierrat B et al., 1998, "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38.alpha. mitogen-activate protein kinase (p38.alpha..sup.MAPK)" J. Biol. Chem. 273(45):29661-29671. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Cuenda A, et al., 1996, "Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells" EMBO J. 15(16):4156-4164. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Weigel N, 1996, "Steroid hormone receptors and their regulation by phosphorylation" Biochem J 319:657-667. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Kato S et al., 1995, "Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase" Science 270:1491-1494. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Osborne et al., 1995, "Comparison of the Effects of a Pure Steroidal Antiestrogen With Those of Tamoxifen in a Model of Human Breast Cancer", J Natl Cancer Inst 87(10):746-750. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Fujimoto N et al., 1994, "Alteration in the Agonist/Antagonist Balance of Antiestrogens by Activation of Protein Kinase A Signaling Pathways in Breast Cancer Cells: Antiestrogen Selectivity and Promoter Dependence" Mol Endocrinol. 8(3):296-304. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Osborne CK et al., 1994, "Mechanisms of tamoxifen resistance", Breast Cancer Res Treat. 32:49-55. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Encarnacion CA et al., 1993, "Measurement of steroid hormone receptors in breast cancer patients on tamoxifen" Breast Cancer Res. Treat. 26:237-246. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Early Breast Cancer Trials Collaborative Group, 1992, "Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy" Lancet 339(8785):71-85. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Osborne CK et al., 1991, "Acquired Tamoxifen Resistance: Correlation With Reduced Breast Tumor Levels of Tamoxifen and Isomerization of Trans-4-Hydroxytamoxifen", J Natl Cancer Inst. 83(20):1477-1482. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Saez R et al., 1989, Hormonal Treatment of Advanced Breast Cancer Hormone Therapy of Breast Cancer, pp. 163-172. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. AF012108; Aug. 19, 1997; Homo Sapeins Amplified in Breast Cancer (AIBI) mRNA, Complete CDs; Last Accesses May 25, 2006; www.ncbi.nlm.nih.gov; p. 4. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. BD192354; Jul. 17, 2003; AIB1, A Steroid Receptor Co-Activator; Last Accessed May 25, 2006; www.ncbi.nim.nih.gov; p. 3. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. AAC51677; Aug. 13, 1997; Amplified in Breast Cancer [Homo Spanies]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
S.L. Anzick et al.; "AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer"; Science, vol. 277; pp. 965-968, Aug. 15, 1997. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. NP.sub.--001871; Mar. 19, 1999; cAMP Responsive Element Binding Protein 2 [Homo Sapiens]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. NM.sub.--001880; Mar. 19, 1999; Homo Sapiens cAMP Responsive Element Binding Protein 2 (CREB2) mRNA; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
T. Maekawa et al.; "Leucine Zipper Structure of the Protein CRE-BP1 Binding to the Cyclic AMP Response Element in Brain"; The EMBO Journal, vol. 8, No. 7; pp. 2023-2028. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. S40706; Sep. 28, 1992; GADD153=growth arrest and DNA-damage-inducible gene[human, Genomic/mRNA, 895 nt]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. S40706; Sep. 28, 1992; Gadd153 [human, Peptide, 168 aa]; Last Accessed May 25, 2006; ; www.ncbi.nlm.nih.gov; p. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. CR542252; Jun. 29, 2004; Homo sapiens full open reading frame cDNA clone RZPDo834C0626D for gene ELK1, ELK1, member of ETS oncogene family,; complete cds, incl. stopcodon; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 3. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. CAG47048; Jun. 29, 2004; ELK1 [Homo sapiens]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. NM.sub.--000125; Mar. 19, 1999; Homo sapiens estrogen receptor 1 (ESR1) mRNA; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 5. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. NP.sub.--000116; Mar. 19, 1999; Estrogen receptor 1 [Homo sapiens]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 4. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
S. Mosselman et al.; "ER.beta.: Identification and Characterization of a Novel Human Estrogen Receptor"; FEBS Lettes, vol. 392; pp. 49-53, Aug. 19, 1996. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. NM.sub.--001437; Oct. 17, 2000; Homo sapiens estrogen receptor 2 (ER beta) (ESR2), mRNA; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. NP.sub.--001428; Oct. 17, 2000; Estrogen receptor 2 (ER beta) [Homo sapiens]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. X68505; Oct. 13, 1992; H. sapiens mRNA for myocyte-specific enhancer factor 2 (MEF2); Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 3. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. X68505; Oct. 13, 1992; Myocyte-specific enhancer factor 2 (MEF2); Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. P49137; Feb. 1, 1996; MAP Kinase-Activated Protein Kinase 2 (MAPK-Activated Protein Kinase 2) (MAPKAP Kinase 2) (MAPKAPK-2);Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 3. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
A.J. Waskiewicz et al.; "Mitogen-activayed protein kinase activated the serine/theonine kinases Mnk1 and Mnk2"; The EMBO Journal, vol. 16, No. 8; pp. 1909-1920, Apr. 15, 1997. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
M. Deak et al.; "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p. 38, and may mediate activation of CREB"; The EMBO Journal, vol. 17, No. 15; pp. 4426-4441, Aug. 3, 1998. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. AF074393; Aug. 10, 1998; Homo sapiens nuclear mitogen-and stress-activated protein kinase-1 (MSK1) mRNA, complete cds; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 3. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. AAC31171; Aug. 10, 1998; Nuclear mitogen- and stress-activated protein kinase-1 [Homo sapiens]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
J. C. Lee et al., "A protein kinase involved in the regulation of inflammatory cytokine. biosynthesis"; Nature Articles, vol. 372; pp. 739-746, Dec. 22-29, 1994. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. L35263; Dec. 22, 1994; Human Csaids binding protein (CSBP1) mRNA, complete cds; Last Accessed May 25, 2006; www.ncbi.nih.gov; pp. 3. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. Q16539; Feb. 1, 1997; Mitogen-Activated Protein Kinase p38 (MAP Kinase p38) (Cytokine Suppressive Anti-Inflammatory Drug Binding Protein) (Csaid Binding Protein) (CSBP) (Max-Interacting Protein 2) (MAP kinase MXI2); Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 3. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Y. Jiang et al.; "Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38.beta.)"; The Journal of Biological Chemistry, vol. 271, No. 30; pp. 17920-17926, Jul. 26, 1996. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. NM.sub.--139014; May 20, 2002; Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 4, mRNA; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 5. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. U53442; Jul. 30, 1996; Human p38Beta MAP kinase mRNA, complete cds; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Y. Jiang et al.; Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38.sigma.; Jour. Bio. Chem., vol. 272, No. 48; pp. 30122-30128, Jul. 26, 1996. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. NP.sub.--620583; May 20, 202; Mitogen-activated protein kinase 14, isoform 4; cytokine suppressive anti-inflammatory drug binding protein; Csaids binding protein; MAP kinase Mxi2; p38 mitogen activated protein kinase; p38 MAP kinase; p38alpha Exip; stress-activated protein kinase 2A; MAX-interacting protein 2 [Homo sapiens]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 4. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
X.S. Wang et al.; "Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase"; Journal of Biological Chemistry, vol. 272, No. 38; pp. 23668-23674, Sep. 19, 1997. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. AF015256; Sep. 8, 1997; Homo sapiens p38 mitogen-activated kinase (p38 delta) mRNA, complete cds; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. AF015256; Aug. 22, 1997; p38 mitogen-activated protein kinase [Homo sapiens]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. X79483; Jun. 6, 1996; Homo sapiens ERK5 mRNA for extracellular signal regulated kinase; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. X79483.8; Jun. 6, 1996; Extracellular signal regulated kinase; Last Accessed May 25, 2006; www. ncbi.nlm.nih.gov; p. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
C. Lechner et al.; "ERK6, A Mitogen-activated Protein Kinase involved in C2C12 Myoblast Differentiation"; Proc. Natl. Acad. Sci., vol. 93; pp. 4355-4359, Apr. 30, 1996. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
L. New et al.; "PRAK, a novel protein kinase regulated by the p38 MAP kinase"; The EMBO Journal, vol. 17, No. 12; pp. 3372-3384, Jun. 15, 1998. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. AF032437; May 16, 1998; Homo sapiens mitogen-activated protein kinase activated protein kinase gene, complete cds; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. NP.sub.--620777; May 28, 2002; Mitogen-activated protein kinase-activated protein kinase 5, isoform 2, p38-regulated/activated protein kinase [Homo sapien]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 3. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
B. Pierrat et al.; "RSK-B, a Novel Ribosomal S6 Kinase Family Member, Is a CREB Kinase under Dominant Control of p38.alpha. Mitogen-activated Protein Kinase (p38.alpha. MAPK)"; The Journal of Biological Chemistry, vol. 273, No. 45; pp. 29661-29671, Nov. 6, 1998. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. NM.sub.--003942; Mar. 19, 1999; Homo sapiens ribosomal protein S6 kinase, 90kD, polypeptide 4 (RPS6KA4) mRNA; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 3. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. AJ010119; Aug. 25, 1998; Ribosomal protein kinase B (RSK-B) [Homo sapiens]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; p. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
NCBF Accession No. AAW56072; Jan. 19, 2005; Signal Transducer and activator of transcription 1, 91kDa [Homo sapiens]; Last Accessed May 25, 2006; www.ncbi.nlm.nih.gov; pp. 2. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Osborne CK et al., 1987, "Human Breast Cancer in the Athymic Nude Mouse: Cytostatic Effects of Long-term Antiestrogen Therapy" Eur J Cancer Clin Oncol. 23(8):1189-1196. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Hoogstraten B et al., 1984, Combined Modality Therapy for First Recurrence of Breast Cancer Cancer 54(10):2248-2256. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Pritchard Kl et al., 1980, "Tamoxifen Therapy in Premenopausal Patients With Metastatic Breast Cancer" Cancer Treat Rep. 64(6-7):787-96. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Gutierrez et al., Molecular Changes in Tamoxifen-Resistant Breast Cancer: Relation Between Estrogen Receptor, HER-2, and p38 Mitogen-Activated Protein Kinase, J. Clin. Oncol.,23:2469-2476 , Apr. 10, 2005. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Lee et al., Regulation of Estrogen Receptor Nuclear Export by Ligand-Induced and p38-Mediated Receptor Phosphorylation, Mol. Cell. Biol., 22:5835-5845, Aug. 2002. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Wu et al., Selective Phosphorylations of the SRC-3/AIB1 Coactivator Integrate Genomic Responses to Multiple Cellular Signaling Pathways, Mol. Cell, 15:937-949, Sep. 24, 2004. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Gutierrez MC, Detre S, Johnston S, Mohsin SK, Shou J, Allred DC, Schiff R, Osborne CK, Dowsett M. Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase. J Clin Oncol. Apr. 10, 2005;23(11):2469-76. Epub Mar. 7, 2005. cited by other . Aug,2008	Your vote accepted [0 after 0 votes]
Lee JC, Kumar S, Griswold DE, Underwood DC, Votta BJ, Adams JL. Inhibition of p38 MAP kinase as a therapeutic strategy. Immunopharmacology. May 2000;47(2-3):185-201. cited by other. Aug,2008	Your vote accepted [0 after 0 votes]
[Vote on relevancy & make comments]