The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
1. CROSS REFERENCE TO RELATED APPLICATIONS
This application is a divisional of Ser. No. 10/858,343 filed Jun. 1, 2004, now issued as U.S. Pat. No. 7,060,827, which is a continuation of Ser. No. 10/355,543 filed Jan. 31, 2003, now pending, which claims benefit under 35 U.S.C. .sctn. 119(e) to application Ser. No. 60/353,333 filed Feb. 1, 2002; and claims benefit of application Ser. No. 60/353,267 filed Feb. 1, 2002; and claims benefit of application Ser. No. 60/399,673 filed Jul. 29, 2002; and claims benefit of application Ser. No. 60/434,277 filed Dec. 17, 2002. The contents of application Ser. Nos. 10/858,343 and 10/355,543 are incorporated herein by reference.
