A seat mount structure for a saddle ride vehicle having seat brackets provided on a vehicle body frame, includes hooks on a bottom plate of a seat, and locking the hooks to the seat brackets to thereby mount the seat to the vehicle body frame. The structure also includes front-side cushion rubbers for receiving the load on the seat side mounted to the seat brackets, the front-side cushion rubbers being located on the inner side of the hooks. With this seat mount structure for a saddle ride vehicle, a bending moment at a lock portion between the vehicle body frame side and the seat side is suppressed, and the ride comfort is enhanced while setting the moldability of a seat bottom plate to be equivalent to that in the related art.