A pistol with interchangeable grip comprising a frame (12) adapted to receive an interchangeable grip (13), in which engagement means for the locking and release of the grip are arranged coupled to the frame (12) and to the grip (13) and comprise a pin or peg (20), moveable within a seat (21) of the frame (12) from a first position of engagement in a seat (23) formed on an inner surface of a side wall (13A) of the grip (13) to a second position disengaged from this.
