Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.
This application is a continuation of U.S. patent application Ser. No. 09/870,379, filed May 30, 2001 which is a .sctn.371 application of PCT/US 01/17358, which in turn claims priority under 35 U.S.C. .sctn.119(e) to U.S. Provisional Application Nos. 60/208,437 and 60/274,167 filed May 30, 2000 and Mar. 8, 2001 respectively. The entire disclosures of each of the above-identified applications is incorporated by reference herein.
