The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
This non-provisional application claims the benefit of priority under 35 U.S.C. .sctn. 119(e) from U.S. Provisional Patent Application Ser. Nos. 60/465,424, 60/465,373, 60/465,420, 60/465,380, 60/465,433, 60/465,481, 60/465,377, 60/465,581, 60/465,532, 60/465,844, 60/465,531, and 60/465,574, all filed Apr. 25, 2003; and to U.S. Provisional Patent Application Ser. Nos. 60/493,303, 60/493,310, 60/493,309, and 60/493,302, all filed Aug. 7, 2003; and to U.S. Provisional Patent Application Ser. Nos. 60/495,533, 60/495,529, 60/495,455, 60/495,537, 60/495,456, 60/495,398, 60/495,425, 60/495,427, 60/495,661, 60/495,393, 60/495,416, 60/495,614, and 60/495,417, all filed Aug. 15, 2003; and to U.S. Provisional Patent Application Ser. Nos. 60/514,054, 60/513,971, 60/514,394, 60/513,975, 60/514,453, 60/514,202, 60/513,948, 60/514,424, 60/514,280, 60/514,144, 60/513,979, 60/514,075, 60/513,946, 60/514,051, 60/514,161, 60/514,325, 60/514,044, 60/514,201, 60/514,522, 60/514,140, 60/514,175, 60/514,113, 60/513,562, 60/513,592, 60/513,563, 60/513,579, 60/513,561, 60/513,589, 60/513,593, 60/513,588, 60/514,258, 60/514,021, and 60/514,298, all filed Oct. 24, 2003; and to U.S. Provisional Patent Application Ser. Nos. 60/532,230, 60/531,960, 60/532,160, 60/531,940, and 60/531,932, all filed Dec. 22, 2003; and to U.S. Provisional Patent Application Ser. No. 60/532,591, filed Dec. 23, 2003; and to U.S. Provisional Patent Application Ser. No. 60/536,005, filed Jan. 12, 2004. The entirety of all Provisional Applications listed above are incorporated herein by reference.
