Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the implanted sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the implanted sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then stimulate toxin release based on the confirmation; and (h) monitor for the expression of a protein produced from a gene therapy modification.In particular embodiments, the intensity of the excitation signals emitted to the localized tissue can be varied in a predetermined manner to generate optical profiling data of the response of the tissue proximate the sensor.
RELATED APPLICATIONS
The present application claims priority to United States Provisional Application Ser. No. 60/448,349 entitled In Vivo Fluorescence Sensors, Systems, and Related Methods Operating in Conjunction with Fluorescently Labeled Materials, filed Feb. 19, 2003 and United States Provisional Application Ser. No. 60/471,706 entitled In Vivo Fluorescence Sensors, Systems, and Related Methods Operating in Conjunction with Fluorescently Labeled Materials, filed May 19, 2003, the entire contents of the above-referenced documents are hereby incorporated herein by reference.
