A hand held quick-clamping device includes an adjusting rod, a retaining handle, a driving handle, a first clamping block, and a second clamping block. The adjusting rod intersects the retaining handle, a set of adjusting sheets, and the stop sheets. A first clamping block is locked in a predetermined end of an adjusting rod, and a second clamping block is formed on a top end of the retaining handle. A driving handle is pivoted to the retaining handle. A traveling top shaft is installed in the retaining handle, and an axial shaft is opposite to it. While the driving handle is pressed, a top end of the driving handle pushes the top shaft. Through the top shaft, the axial shaft pushes the adjusting sheets and the stop sheets. And the movement of the sheets will drive an adjusting rod to move in one direction, thus producing a clamping or extending function.