April 28, 2009

The present invention is directed to a non-human mammal with at least 30% of all of its glial cells in its corpus callosum being human glial cells and/or at least 5% of all of its glial cells in the white matter of its brain and/or brain stem being human glial cells. Methods of producing and using the non-human mammal are also disclosed.

50

April 28, 2009

12/015,372

January 16, 2008

424/93.1   800/21 800/3 800/8

G01N   33/00   (20060101)   A01K   67/00   (20060101)   A01K   67/033   (20060101)   C12N   15/00   (20060101)  

This application claims the benefit of U.S. Provisional Patent Application Ser. No. 60/885,094, filed Jan. 16, 2007.

800/8   800/3   424/93.1