July 28, 2009

Co-crystals and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and several important physical properties are modulated. The solubility, dissolution, bioavailability, dose response, and stability of modafinil can be modulated to improve efficacy in pharmaceutical compositions.

53

July 28, 2009

10/570,405

September 4, 2004

564/162  

C07C   323/22   (20060101)   A61K   31/165   (20060101)  

CROSS REFERENCE TO RELATED APPLICATIONS This application is a .sctn.371 National Stage filing of PCT/US2004/029013 filed Sep. 4, 2004 and claims the benefit of PCT/US2004/006288 filed Feb. 26, 2004, PCT/US2003/027772 filed Sep. 4, 2003 and US provisional applications U.S. Ser. No. 60/542,752 filed Feb. 6, 2004, U.S. Ser. No. 60/560,411 filed Apr. 6, 2004, U.S. Ser. No. 60/573,412 filed May 21, 2004, 60/579,176 filed Jun. 12, 2004, U.S. Ser. No. 60/581,992 filed Jun. 22, 2004, U.S. Ser. No. 60/586,752 filed Jul. 9, 2004, U.S. Ser. No. 60/588,236 filed Jul. 15, 2004, U.S. Ser. No. 60/508,208 filed Oct. 2, 2003 and non-provisional application U.S. Ser. No. 10/660,202 filed Sep. 11, 2003. This application is a 371 of PCT/US/04/29013, filed Sep. 4, 2003, which claims the benefit of PCT/US/03/2772, filed Sep. 4, 2003, U.S. Ser. No. 10/660,202, filed Sep. 11, 2003, U.S. Ser. No. 60/508,208, filed Oct. 2, 2003, U.S. Ser. No. 60/542,752, filed Feb. 6, 2004, PCT/US/04/06288, filed Feb. 26, 2004, U.S. Ser. No. 60/560,411, filed Apr. 6, 2004, U.S. Ser. No. 60/573,412, filed May 21, 2004, U.S. Ser. No. 60/579,176, filed Jun. 12, 2004, U.S. Ser. No. 60/581,992, filed Jun. 22, 2004, U.S. Ser. No. 60/586,752, filed Jul. 9, 2004, and U.S. Ser. No. 60/588,236, filed Jul. 15, 2004. This application is also a continuation-in-part of U.S. application Ser. No. 10/660,202, filed Sep. 11, 2003, which claims the benefit of PCT/US03/27772, filed Sep. 4, 2003. Said U.S. application Ser. No. 10/660,202, filed Sep. 11, 2003 also claims the benefit of U.S. application Ser. No. 10/637,829, filed Aug. 8, 2003, which is a divisional of U.S. application Ser. No. 10/295,995, filed Nov. 18, 2002, which is a continuation of U.S. application Ser. No. 10/232,589, filed Sep. 3, 2002, which claims the benefit of U.S. Provisional Application No. 60/406,974, filed Aug. 30, 2002, U.S. Provisional Application No. 60/380,288, filed May 15, 2002, and U.S. Provisional Application No. 60/356,764, filed Feb. 15, 2002. Said U.S. application Ser. No. 10/660,202, filed Sep. 11, 2003, is also a continuation-in-part of U.S. application Ser. No. 10/449,307, filed May 30, 2003, which claims the benefit of U.S. Provisional Application No. 60/463,962, filed Apr. 18, 2003, U.S. Provisional Application No. 60/444,315, filed Jan. 31, 2003, U.S. Provisional Application No. 60/439,282, filed Jan. 10, 2003, and U.S. Provisional Application No. 60/384,152, filed May 31, 2002. Said U.S. application Ser. No. 10/660,202, filed Sep. 11, 2003, is also a continuation-in-part of U.S. application Ser. No. 10/601,092, filed Jun. 20, 2003. Said U.S. application Ser. No. 10/660,202, filed Sep. 11, 2003, also claims the benefit of U.S. Provisional Application No. 60/451,213, filed Feb. 28, 2003, U.S. Provisional Application No. 60/463,962, filed Apr. 18, 2003, and U.S. Provisional Application No. 60/487,064, filed Jul. 11, 2003. This application is also a continuation-in-part of Application No. PCT/US04/06288, filed Feb. 26, 2004, which claims the benefit of U.S. Provisional Application No. 60/451,213, filed Feb. 28, 2003, U.S. Provisional Application No. 60/487,064, filed Jul. 11, 2003, Application No. PCT/US03/27772, filed Sep. 4, 2003, U.S. application Ser. No. 10/660,202, filed Sep. 11, 2003, Application No. PCT/US03/06662, filed Mar. 3, 2003, U.S. Provisional Application No. 60/508,208, filed Oct. 2, 2003, U.S. Provisional Application No. 60/542,752, filed Feb. 6, 2004, U.S. Provisional Application No. 60/463,962, filed Apr. 18, 2003, U.S. application Ser. No. 10/449,307, filed May 30, 2003, U.S. Provisional Application No. 60/456,027, filed Mar. 18, 2003, U.S. application Ser. No. 10/601,092, filed Jun. 20, 2003, Application No. PCT/US03/19574, filed Jun. 20, 2003, and Application No. PCT/US03/41273, filed Dec. 24, 2003. This application also claims the benefit of U.S. Provisional Application No. 60/508,208, filed Oct. 2, 2003, U.S. Provisional Application No. 60/542,752, filed Feb. 6, 2004, U.S. Provisional Application No. 60/560,411, filed Apr. 6, 2004, U.S. Provisional Application No. 60/573,412, filed May 21, 2004, U.S. Provisional Application No. 60/579,176, filed Jun. 12, 2004, U.S. Provisional Application No. 60/581,992, filed Jun. 22, 2004, U.S. Provisional Application No. 60/586,752, filed Jul. 9, 2004, and U.S. Provisional Application No. 60/588,236, filed Jul. 15, 2004. All of the applications above, to which a benefit is claimed, are herein incorporated by reference in their entireties.

Sep 04, 2003 [WO] PCT/US03/27772 Feb 26, 2004 [WO] PCT/US2004/006288