September 8, 2009

An article for use in an aerosol device, for producing an aerosol of a drug composition is disclosed. The article includes a heat-conductive substrate having a surface with a selected surface area, and a drug composition film on the substrate surface having a selected film thickness of between 0.05 and 20 .mu.m. The film thickness is such that an aerosol formed by vaporizing the drug composition by heating the substrate and condensing the vaporized compound contains 10% or less drug-degradation product and at least 50% of the total amount of drug composition contained in the film. The selected substrate surface area is such as to yield an effective human therapeutic dose of the drug aerosol. Also disclosed are methods of making and using the article.

12

September 8, 2009

10/633,877

August 4, 2003

424/45   128/200.14 128/200.15 128/200.24 424/434 424/46 424/489 424/499 514/958

A61K   9/12   (20060101)   A61K   9/14   (20060101)   A61M   15/00   (20060101)  

The present application is a continuation-in-part of application Ser. No. 10/057,197, filed Oct. 26, 2001, which claims benefit of Provisional Application No. 60/296,225, filed Jun. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/057,198, filed Oct. 26, 2001, which claims benefit of Provisional Application No. 60/296,225, filed Jun. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/146,080, filed May 13, 2002, which is a continuation-in-part of application Ser. No. 10/057,198, filed Oct. 26, 2001, which claims the benefit of Provisional Application No. 60/296,225, filed Jun. 5, 2001. This Application is also a continuation-in-part of application Ser. No. 10/057,197, filed Oct. 26, 2001, which claims the benefit of Provisional Application No. 60/296,225, filed Jun. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/146,086, filed May 13, 2002. This application is also a continuation-in-part of application Ser. No. 10/146,088, filed May 13, 2002, which is a continuation-in-part of patent application Ser. No. 10/057,198, filed Oct. 26, 2001, which claims the benefit of Provisional Application No. 60/296,225, filed Jun. 5, 2001. This application is also a continuation-in-part of patent application Ser. No. 10/057,197, filed Oct. 26, 2001, which claims the benefit of Provisional Application No. 60/296,225, filed Jun. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/146,515, filed May 13, 2002, now U.S. Pat. No. 6,682,716, which is a continuation-in-part of patent application Ser. No. 10/057,198, filed Oct. 26, 2001, which claims the benefit of Provisional Application No. 60/296,225, filed Jun. 5, 2001. This application is also a continuation-in-part of patent application Ser. No. 10/057,197, filed Oct. 26, 2001, which claims the benefit of Provisional Application No. 60/296,225, filed Jun. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/146,516, filed May 13, 2002, now U.S. Pat. No. 6,737,042, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and also claims the benefit of Provisional Application No. 60/317,479, file Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/150,056, filed May 15, 2002, now U.S. Pat. No. 6,805,853, which claims the benefit of Provisional Application No. 60/345,882, filed Nov. 9, 2001. This application is also a continuation-in-part of application Ser. No. 10/150,267, filed May 15, 2002, now U.S. Pat. No. 6,797,259, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/150,268, filed May 15, 2002, now U.S. Pat. No. 6,780,399, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/150,591, filed May 17, 2002, now U.S. Pat. No. 6,780,400, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/150,857, filed May 17, 2002, now U.S. Pat. No. 6,716,415, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/151,596, filed May 16, 2002, now U.S. Pat. No. 6,855,310, which claims the benefit of Provisional Application. No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/151,626, filed May 16, 2002, now U.S. Pat. No. 6,783,753, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/152,639, filed May 20, 2002, now U.S. Pat. No. 6,716,416, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/152,640, filed May 20, 2002, now U.S. Pat. No. 6,743,415, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and pr Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/152,652, filed May 20, 2002, now U.S. Pat. No. 6,740,307, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/153,139, filed May 20, 2002, now U.S. Pat. No. 6,814,954, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/153,311, filed May 21, 2002, now U.S. Pat. No. 6,884,408, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/153,313, filed May 20, 2002, now abandoned which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001, and of Provisional Application No. 60/345,145, filed Nov. 9, 2001. This application is also a continuation-in-part of application Ser. No. 10/153,831, filed May 21, 2002, now U.S. Pat. No. 6,740,308, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/153,839, filed May 21, 2002, now U.S. Pat. No. 6,776,978, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/154,594, filed May 23, 2002, now U.S. Pat. No. 6,740,309, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/154,765, filed May 23, 2002, now U.S. Pat. No. 6,814,955, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/155,097, filed May 23, 2002, now U.S. Pat. No. 6,716,417, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/155,373, filed May 22, 2002, now U.S. Pat. No. 6,737,043, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001, and of Provisional Application No. 60/345,876, filed Nov. 9, 2001. This application is also a continuation-in-part of application Ser. No. 10/155,621, filed May 22, 2002, now U.S. Pat. No. 6,759,029, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001, and of Provisional Application No. 60/332,280, filed Nov. 21, 2001, and of Provisional Application No. 60/336,218, filed Oct. 30, 2001. This application is also a continuation-in-part of application Ser. No. 10/155,703, filed May 22, 2002, now U.S. Pat. No. 6,803,031, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/155,705, filed May 22, 2002, now U.S. Pat. No. 6,805,854, which claims the benefit of Provisional Application No. 60/294,203, filed May 24, 2001, and of Provisional Application No. 60/317,479, filed Sep. 5, 2001. This application is also a continuation-in-part of application Ser. No. 10/280,315, filed Oct. 25, 2002, now abandoned which claims the benefit of Provisional Application No. 60/335,049, filed Oct. 30, 2001, and of Provisional Application No. 60/371,457, filed Apr. 9, 2002. This application is also a continuation-in-part of application Ser. No. 10/302,010, filed Nov. 21, 2002, now U.S. Pat. No. 7,078,016, which claims the benefit of Provisional Application No. 60/332,279, filed Nov. 21, 2001. This application is also a continuation-in-part of application Ser. No. 10/302,614, filed Nov. 21, 2002, which claims the benefit of Provisional Application No. 60/332,165, filed Nov. 21, 2001. This application is also a continuation-in-part of application Ser. No. 10/322,227, filed Dec. 17, 2002, now abandoned which claims the benefit of Provisional Application No. 60/342,066, filed Dec. 18, 2001, and of Provisional Application No. 60/412,068, filed Sep. 18, 2002.

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