There are disclosed macrolides isolated from the fermentation broth, with avermectin Bla, avermectin Blb or 22,23-dihydro avermectin Bla as a substrate, of a known microorganism identified as MA-6181. The structure of the novel compounds isolated from the microorganism are presented based upon analytical studies. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents. Compositions for such uses are also disclosed.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of our copending application Ser. No. 759,780 filed July 29, 1985 now abandoned.
A novel antibiotic complex, A59770, individual factors and derivatives thereof, are provided. The A59770 compounds are useful as pesticides, particularly as rodenticides. Further provided are methods for reducing a rodent population, rodenticidal compositions, and an A59770-producing Amycolatopsis orientalis culture.
Microorganism growth in aqueous systems used for degradation of ether-based compounds such as MTBE is stimulated and maximized by utilizing fatty acids as the growth substrate for the microorganisms. The fatty acid functions as an inexpensive growth substrate that can be introduced into the aqueous system to quickly maximize the growth of the active microbe incorporated therein. Such a characteristic is desirable since fatty acids are non-toxic, water soluble, typically inexpensive and readily available. In one preferred embodiment, the fatty acid is food grade lactate.
There are disclosed novel compounds which are derived from 22,23-dihydro avermectin B1 aglycone. The compounds are both isomers of the 27-hydroxy adduct of the substrate avermectin compound that have been glycosylated at the 4" position to yield 4"-O-glucosyl 27-OH avermectin compounds. The compounds and the intermediates used to make them are highly potent antiparasitic, insecticidal and anthelmintic avermectin agents.
