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Patent 5106981
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Document Number
US Patent 5106981
Issued Date
April 21, 1992
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Inventors
Klaus; Michael (Weil am Rhein,DE)
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Abstract
Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 each independently are lower-alkyl; or together are alkylene with 3-5 C-atoms in a straight chain; one of the residues R.sup.3 and R.sup.4 is hydrogen and the other is hydrogen or lower-alkyl; R.sup.6 and R.sup.7 are hydrogen or lower-alkyl; R.sup.5 and R.sup.8 are hydrogen, lower-alkyl, lower-alkoxy or halogen; X signifies --O--, --S--, --SO--, --SO.sub.2 -- or --NR.sup.9 ; R.sup.9 is hydrogen, lower-alkyl or acyl; Y is --S(O).sub.m R.sup.10 or --NHet and, where X is --NR.sup.9 --, --S--, --SO-- or --SO.sub.2 --, also --N(R.sup.11).sub.2 or --OR.sup.12 ; R.sup.10 is lower-alkyl; R.sup.11 and R.sup.12 are hydrogen, lower-alkyl or acyl; --NHet is a 5-8 membered, saturated or unsaturated, monocyclic heterocycle attached via a N-atom; n is 2, 3 or 4 and m is 0, 1 or 2, are described. The compounds of formula I are useful as agents for the treatment of disorders such as neoplasms, dermatoses or ageing of the skin.
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Number of Claims:
7
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Owner
Published
April 21, 1992
Application Number
07/510,705
Filed
April 19, 1990
US Classification
546/195   546/184 546/192
Int'l Classification
C07C   211/00   (20060101)   C07C   317/00   (20060101)   C07C   211/10   (20060101)   C07C   317/18   (20060101)   C07C   323/00   (20060101)   C07C   323/25   (20060101)   C07C   323/12   (20060101)   C07D   295/092   (20060101)   C07D   295/00   (20060101)   C07D   295/13   (20060101)  
Assistant Examiner
Parent Case
This is a division of application Ser. No. 07/310,442, filed Feb. 14, 1989, now U.S. Pat. No. 4,940,707.
Priority Data
Feb 24, 1988 [CH] 689/88 Dec 14, 1988 [CH] 4622/88
USPTO Field of Search
546/195   546/192   546/184   514/277   514/279  
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