The invention relates to a new process for the depletion of 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-[(Z)-1-propen-1-yl]-3-cephem-4-carboxylic acid and 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-[(Z/E)-1-propen-1-yl]-3-cephem-4-carboxylic acid or by adsorption chromatography.
This application is a divisional of U.S. application Ser. No. 08/466,306, filed Jun. 6, 1995, now U.S. Pat. No. 5,869,648, which is a continuation of U.S. application Ser. No. 08/284,515, filed Aug. 5, 1994 now abandoned. The entire contents of the '306 application and the '515 application are incorporated herein by reference which is a 371 of PCT/EP92/02965 Dec. 21, 1992.
Priority Data
Feb 05, 1992 [AT] 191/92 Dec 09, 1992 [GB] 9225666
