##STR00001## Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, A, D, X, Y and Z have the meaning as defined in the claims exhibit protein tyrosine kinase and protein serin/threonine kinase inhibitory activity.
This application is a divisional of U.S. Ser. No. 09/966,318 filed on Sep. 27, 2001 now U.S. Pat. No. 6,818,632 which is a divisional of U.S. Ser. No. 09/514,528 filed on Feb. 28, 2000 now U.S. Pat. No. 6,350,747.
Disclosed herein are compounds of Formula (I), (II), and (III) ##STR00001## pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.
