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Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation



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Patent 7368591
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Document Number
US Patent 7368591
Issued Date
May 6, 2008
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Abstract
The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). ##STR00001## wherein n, Y, R.sub.1, R.sub.1a, R.sub.2 and R.sub.2a are as defined in claim 1.
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Number of Claims:
37
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Owner
Cephalon France (Maisons Alfort,FR)
Published
May 6, 2008
Application Number
11/082,530
Filed
March 17, 2005
US Classification
560/9   560/11
Int'l Classification
C07C   321/00   (20060101)  
Examiner
Attorney/Law Firm
Parent Case
CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part of U.S. application Ser. No. 10/943,360, filed Sep. 17, 2004, which in turn claims priority of European Application No. EP 03292312.0, filed Sep. 19, 2003 and U.S. Provisional Application Ser. No. 60/507,089, filed Oct. 10, 2003. The disclosures of these priority applications are incorporated herein by reference in their entireties for all purposes.
Priority Data
Sep 19, 2003 [EP] 03292312.0
USPTO Field of Search
560/9   560/11  
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