S-nitrosohemoglobin can liberate NO by transfer to a low molecular weight thiol in the circulatory system, allowing the delivery of NO to the tissues. The effect of administering isolated S-nitrosohemoglobin and low molecular weight thiol to a mammal is to increase delivery of oxygen and NO.
RELATED APPLICATIONS
This application is a continuation of U.S. application Ser. No. 10/638,969 filed on Aug. 11, 2003, now U.S. Pat. No. 7,202,340, which is a continuation of U.S. application Ser. No. 09/369,966 filed on Aug. 6, 1999, now U.S. Pat. No. 6,627,738, which is a continuation of PCT/US98/02383 filed on Feb. 5, 1998, which is a continuation-in-part of U.S. application Ser. No. 08/874,992 filed on Jun. 12, 1997, now U.S. Pat. No. 6,911,427, which is a continuation-in-part of U.S. application Ser. No. 08/796,164 filed on Feb. 6, 1997, now U.S. Pat. No. 6,884,773, which is a continuation-in-part of PCT/US96/14659 filed on Sep. 13, 1996, which is a continuation of U.S. application Ser. No. 08/667,003 filed on Jun. 20, 1996, now U.S. Pat. No. 6,197,745, which is a continuation-in-part of U.S. application Ser. No. 08/616,371 filed on Mar. 15, 1996, now U.S. Pat. No. 6,855,691, which claims the benefit of U.S. Provisional Application No. 60/003,801 filed on Sep. 15, 1995. The teachings of all of the above applications are each incorporated herein by reference in their entirety.
