Disclosed are cyclic imino oligomers and polymers comprised of subunits of the formula: ##STR00001## Also disclosed are combinatorial libraries and arrays of the cyclic imino compounds.

In a process for preparing bis(2-morpholinoethyl) ether by reacting diethylene glycol with ammonia under superatmospheric pressure and at elevated temperature in the presence of hydrogen and a hydrogenation catalyst, the catalytically active composition of the catalyst prior to reduction with hydrogen comprises from 20 to 85% by weight of aluminum oxide (Al.sub.2 O.sub.3), zirconium dioxide (ZrO.sub.2), titanium dioxide (TiO.sub.2) and/or silicon dioxide (SiO.sub.2), from 1 to 70% by weight of o...

The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nitrogens. In addition, at least one of the ring nitrogens is quatranized and linked to a hydrocarbon having at least one heteroatom.

Piperazines of the formula in which R is a straight or branched chain alkyl radical, which may be substituted by a hydroxyl, of one to seven carbon atoms, a cinnamyl radical, or a radical of the formula in which Z is hydroxy, alkoxy or a heterocyclic radical. The compounds are prepared by alkylating an N substituted piperazine with 2-bromo-6-methyl 5-heptene and then hydrating the reaction product in a sulfuric acid medium. The compounds may be incorporated with therapeutically acceptable carrie...

A process for preparing piperazine is provided wherein an amino compound such as amines of the general formula X--ch.sub.2 ch.sub.2 --y wherein X is --NH.sub.2 or --OH and Y is --NH-- CH.sub.2 --CH.sub.2 --OH, --NH--(CH.sub.2 CH.sub.2 NH).sub.n --H or wherein n is 0 to 3 or mixtures of such amines obtained by reaction between ethylene oxide and ammonia, is heated in the presence of ammonia, if necessary, and a Ni--MgO catalyst at a temperature from about 200.degree. to about 275.degree. C to a p...

The invention relates to benzene derivatives, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of psychotic disorders.

The invention relates to new .alpha.-arylethylpiperazine of the formula ##STR1## wherein Z represents 0 or S; n' represents 1 or 2; R.sup.2 represents a hydrogen atom or a methyl group; W, Ar.sup.1 and Ar.sup.2 represent various substituents as defined herein; or non-toxic pharmaceutically acceptable salt, individual optical isomer, or individual diastereoisomer thereof, which are useful as neurokinin receptor antagonists (NK.sub.1 antagonists). It also relates to processes for their preparation...

A process for preparing a 1-aryl-4-(arylethyl)piperazine of the formula (I) ##STR1## by reacting a 1-arylpiperazine of the formula (II) ##STR2## with an aromatic olefin of the formula (III) in an inert solvent in the presence of at least one basic catalyst, where in the formulae (I) to (III) Ar and Ar' independently of one another are an aryl radical, selected from the group of the fused and unfused C.sub.6 -C.sub.22 -aromatics and the fused or unfused C.sub.5 -C.sub.22 -heteroaromatics which ha...

A new improved process for synthesizing morpholinylbenzenes of the formula I by reacting morpholine of formula II with a substituted benzene of formula III, wherein morpholine is used as a reactant and as the only one solvent. ##STR1##

The present invention relates to piperazine based amphilic cationic lipids useful for gene therapy, transfection, and introducing immunogenic compounds for the purpose of vaccination. The disclosed compounds have lipophilic moieties linked to the ring nitrogens. In addition, at least one of the ring nitrogens is quatranized and linked to a hydrocarbon having at least one heteroatom.