Processes for using a compound of formula III: ##STR00001## to make compounds of formulae I and II: ##STR00002## and processes for making the compound of formula III, where R.sub.1-5 and J are as defined herein.

Substituted N-sulfamoyl pyridine compounds are useful in the destruction and prevention of weeds and unwanted plants.

The compounds of the formula CH.sub.3 SO.sub.2 CX.sub.2 SO.sub.2 NR.sub.1 R.sub.2 in which X is chloro or bromo and R.sub.1 and R.sub.2 independently are hydrogen, 1 to 16 carbon atom alkyl, phenyl or substituted phenyl and together with the nitrogen atom represent a heterocycle which may contain an oxygen atom or another nitrogen atom in the heterocycle. The compounds are prepared by reacting the corresponding 1-(methylsulfonyl)methanesulfonamide with alkali metal hypohalite in the presence of ...

Brominated sulfoacetic acid amides of the formula R.sub.1 R.sub.2 NCOCBr.sub.x H.sub.2.sub.-x SO.sub.2 NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2 are independently selected from hydrogen and lower alkyl or, in conjunction with the nitrogen atom, from a heterocycle which may contain an oxygen hetero atom and x is an integer from 1 to 2. The compounds are prepared by brominating amides of sulfoacetic acid. The compounds have antimicrobial activity.

A class of phenylsulphonyl derivatives wherein the sulphonyl moiety is also attached to an N-arylalkyl-substituted piperazine ring are selective antagonists of the human 5-HT.sub.2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including schizophrenia and other psychotic disorders.

The compounds of the formula ##SPC1## In which R independently is hydrogen, lower alkyl, lower alkoxy, halo or trifluoromethyl; x is 1 to 2; n is 1 to 3, and R.sub.1 and R.sub.2 independently are hydrogen, lower alkyl or phenyl and together with the nitrogen atom form a heterocycle which may contain an oxygen atom as a hetero atom. The compounds are prepared by reacting the corresponding N-substituted-1-(arylthio)methanesulfonamide with small, incremental amounts up to substantially equimolar of...

This application is directed to compounds of the formula ##EQU1## wherein R.sup.1 is lower alkyl; R.sup.2 is hydrogen, lower alkyl or ##EQU2## wherein m is a whole number 2 to 5, n is a whole number 1 to 4 and Y is hydrogen, --OH or --COOR wherein R is hydrogen or lower alkyl; and X is ##EQU3## wherein R.sup.3 is hydrogen or ##EQU4## wherein n and Y have the same meaning given above, R.sup.4 is ##EQU5## wherein n and Y have the same meaning given above and R.sup.5 is lower alkyl. These compounds...

New 4-(substituted-.alpha., .alpha.-dimethyl-1-piperazine pentanoic acids and derivatives which are useful as anti-arteriosclerotic agents are disclosed. These compounds elevate the high density lipoprotein fraction of cholesterol, and also lower the low density lipoprotein fraction of cholesterol.

Compounds of formula (I) ##STR1## wherein n, V, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the specification are matrix metalloproteinase inhibitors.

The present invention is related to new basically substituted ureas having the general Formula I ##STR1## and the pharmaceutically acceptable acid addition salts thereof which produce an improved antiviral activity against DNS- and RNS-viruses. The invention is further related to the treatment of humans or animals suffering from diseases caused by viruses by administering compositions containing such ureas or salts thereof as active agent.